GLYCOLIC ACID 50
Cosmetic grade by Bruno Bock is a restructuring and depilatory agent. The reducing properties of the SH group open the sulfur bridges in the keratin structure of the hair and thus weaken it.Thio glycolic acid (TGA) is the organic compound HSCH2CO2H . It contains both a thiol (mercaptan) and a carboxylic acid. It is a clear liquid with a strong unpleasant odor. It is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.TGA was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. TGA is the precursor to ammonium thioglycolate that is used for permanents. TGA and its derivatives break the disulfide bonds in the cortex of hair. One reforms these broken bonds in giving hair a "perm." Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing. It is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.TGA is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).TGA, usually as its dianion, forms complexes with metal ions. Such complexes have been used for the detection of iron, molybdenum, silver, and tin.Thioglycolic acid is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
- Thioglycolic acid is an intermediate in the production of thiomethoprol (caputril), biotin, thiozinc acid, sodium dithiosuccinate and other pharmaceuticals, and is also an intermediate in the synthesis of cysteine, hormonal agent, and industrial disinfectant. And an important raw material for the synthesis of sulfuric acid.
- Thioglycolic acid is used as antioxidant and stabilizer in pharmaceuticals to enhance the stability of the main drug and prolong the validity period of pharmaceutical preparations. Ammonium and sodium salts of thioglycolic acid are mainly used as curling agents, calcium salts can be used as depilatory agents, polymerization initiators, accelerators and chain transfer agents, and can be used for hair removal before cosmetic surgery and animal experiments.
- Thioglycolic acid is used to make epoxy resin, catalyst of bisphenol A, and it can also be used as the basic raw material for synthesizing PVC transparent plastic and organic antimony and organic tin heat stabilizer.
- Thioglycolic acid is a sensitive reagent for the determination of iron, molybdenum, aluminum, tin, etc., and is an inhibitor of copper sulfide and iron sulfide minerals in beneficiation. In the petrochemical industry and the railway sector, it is used for cleaning and derusting of equipment and rails.
- It can be used as a crystallization nucleating agent in polypropylene processing and molding, as a modifier for coatings and fibers, as a blanket quickening agent, as a stabilizer raw material for polyvinyl chloride and rubber, as a cold perm agent, and as a pharmaceutical intermediate.
- Thioglycolic acid is used as a color developer for the photometric determination of molybdenum, rhenium and iron, and as a compounding masking agent.
Physical Properties:
| Melting Point | −16 °C(lit.) |
| Boiling Point | 96 °C5 mm Hg(lit.) |
| Density | 1.326 g/mL at 20 °C(lit.) |
| Vapour density | 3.2 (vs air) |
| Vapour pressure | 0.4 mm Hg ( 25 °C) |
| Refractive index |
n |
| Flash Point | 126 °C |
| Storage temprature | Store at +2°C to +8°C. |
| Solublity | Chloroform (Sparingly), Methanol (Sparingly) |
| Form | Liquid |
| Colour | Clear |
| Odour | Strong unpleasent |
| PH | 1 |
| Water solublity | Soluble |
| Sensitive | Air sensitive |
| Stability | Air sensitive |
| Chloroform (Sparingly), Methanol (Sparingly) |
| Chloroform (Sparingly), Methanol (Sparingly) |
