PROPYL 4 HYDROXYBENZOATE LR
PROPYL 4 HYDROXYBENZOATE LR
Propyl 4-hydroxybenzoate (PHB), is a p-hydroxybenzoate derivative. It can be prepared by reacting p-hydroxybenzoic acid with n-propanol in the presence of an acidic ionic liquid.It crystallizes in the monoclinic space group P21/c.It is reported to be an endocrine disrupting compound.
It is hydrolyzed to p-hydroxybenzoic acid, conjugated and the conjugates are rapidly excreted in the urine. There is no evidence of accumulation. Acute toxicity studies in animals indicate that propyl paraben is relatively non-toxic by both oral and parenteral routes, although it is mildly irritating to the skin.
Propyl Hydroxybenzoate is soluble 1 in 2500 of water and 1 in 1.5 of alcohol. The solubility of both componds is increased in hot water.
Some research indicates they are safe as used in cosmetics and are preferred over other preservatives to keep a formula stable. These studies also showed parabens did not have any effect when compared to natural hormones in the body.
Some research indicates they are safe as used in cosmetics and are preferred over other preservatives to keep a formula stable. These studies also showed parabens did not have any effect when compared to natural hormones in the body.