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Isoleucine (symbol Ile or I) is an α-amino acid that is used in the biosynthesis of proteins ... Common name: isoleucine, d-isoleucine, l-isoleucine, dl-isoleucineIt is classified as a non-polar, uncharged (at physiological pH), branched-chain, aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it, and must be ingested in our diet. Isoleucine is synthesized from pyruvate employing leucine biosynthesis enzymes in other organisms such as bacteria.[2] It is encoded by the codons AUU, AUC, and AUA.